NFL Week 10 picks and college football betting previews

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The brief

The NFL's Week 10 Sunday slate kicks off, marking the official halfway point of the 2026 season. Matchups include Vikings vs. Packers, Bills vs. Jets and 49ers vs. Cowboys, with primetime games of Steelers vs. Bengals on Sunday Night Football and Chargers vs. Ravens on Monday Night Football. Other games highlighted for betting value include Texans vs. Browns, Jaguars vs. Texans and Seahawks vs. Raiders, the latter featuring Fernando Mendoza's debut as an NFL starter.

Among the individual picks, SportsLine analyst Alex Selesnick recommends backing Lions receiver Amon-Ra St. Brown to exceed 77.5 receiving yards against the Patriots, a game in Munich at 9:30 a.m. ET. He argued that New England ranks 26th in EPA allowed per dropback and that nickel corner Marcus Jones has struggled this season. In the Chiefs vs. Falcons game at 1 p.m. ET, analyst Adam Thompson picked Kansas City to cover a 3-point spread, noting the Falcons have managed just 17 total points over their last two games and have given up at least 30 points three times during a 1-4 stretch. For Texans vs. Browns, analyst Doug suggested Tank Dell to top 30.5 receiving yards after his route share rose to 55% following the bye.S1

Elsewhere in college football, Indiana, ranked No. 6 at 8-1 (5-1 Big Ten), hosts No. 15 USC (7-2, 4-2) in Bloomington as 8.5-point favorites. Indiana's defense is central to its national title hopes, though its offense has stalled and coach Curt Cignetti has not committed to a starting quarterback. Josh Hoover, who transferred from TCU to replace Fernando Mendoza, has been inconsistent and is dealing with an injury, while backup Grant Wilson led a win over Minnesota. USC's offense ranks 15th in SP+ and has been inconsistent, gaining 6.8 yards per play against Ohio State but just 3.2 against Wisconsin. Analyst Michael Leboff recommends the under on 50.5 points at -110 at FanDuel, given that both defenses are strong.S2

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NFL picks against the spread, Week 10 2026: Expert ATS picks, predictions, best bets, player props for Nov. 15

The SportsLine experts have locked in their top Week 10 picks from this week's NFL schedule, see who they are backing and fading here

NFL Week 10 picks and college football betting previews

2 outlets 2 reports
The brief

The NFL's Week 10 Sunday slate kicks off, marking the official halfway point of the 2026 season. Matchups include Vikings vs. Packers, Bills vs. Jets and 49ers vs. Cowboys, with primetime games of Steelers vs. Bengals on Sunday Night Football and Chargers vs. Ravens on Monday Night Football. Other games highlighted for betting value include Texans vs. Browns, Jaguars vs. Texans and Seahawks vs. Raiders, the latter featuring Fernando Mendoza's debut as an NFL starter.

Among the individual picks, SportsLine analyst Alex Selesnick recommends backing Lions receiver Amon-Ra St. Brown to exceed 77.5 receiving yards against the Patriots, a game in Munich at 9:30 a.m. ET. He argued that New England ranks 26th in EPA allowed per dropback and that nickel corner Marcus Jones has struggled this season. In the Chiefs vs. Falcons game at 1 p.m. ET, analyst Adam Thompson picked Kansas City to cover a 3-point spread, noting the Falcons have managed just 17 total points over their last two games and have given up at least 30 points three times during a 1-4 stretch. For Texans vs. Browns, analyst Doug suggested Tank Dell to top 30.5 receiving yards after his route share rose to 55% following the bye.S1

Elsewhere in college football, Indiana, ranked No. 6 at 8-1 (5-1 Big Ten), hosts No. 15 USC (7-2, 4-2) in Bloomington as 8.5-point favorites. Indiana's defense is central to its national title hopes, though its offense has stalled and coach Curt Cignetti has not committed to a starting quarterback. Josh Hoover, who transferred from TCU to replace Fernando Mendoza, has been inconsistent and is dealing with an injury, while backup Grant Wilson led a win over Minnesota. USC's offense ranks 15th in SP+ and has been inconsistent, gaining 6.8 yards per play against Ohio State but just 3.2 against Wisconsin. Analyst Michael Leboff recommends the under on 50.5 points at -110 at FanDuel, given that both defenses are strong.S2

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Sources · 2 citations

S1 CBS Sports 1 report · EN
S2 NypostLead 1 report · EN